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Noopept: Full Review of Clinical Research, Dosage, Withdrawal, and Experiences

Noopept Review
Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester. Noopept may alleviate cognitive decline.

Noopept is a nootropic peptide (which is a naturally-occurring biological molecule) that is derived from cycloprolyglycine, a substance that facilitates memory.

Although different to Piracetam, which also improves memory, increases learning, enhances focus and heightens sensory perception, Noopept is, like Piracetam, categorized as a racetam. Racetams are synthetic compounds that normally have a 2-pyrrolidone nucleus structure (though Noopept doesn’t haven’t the dual structure), and work primarily by stimulating the receptors for acetylcholine, a neurotransmitter and so improving brain function. So Noopept works like other racetams, even though it doesn’t have the same makeup as other racetams like Piracetam.

Noopept is also seen as a substance that supports brain health in general. For this reason it is also categorized as a neuroprotectant, literally helping to protect the brain from damage – rather like anti-oxidants protect the body from toxins. It reduces stress in the brain caused by oxidation, and may even reduce damage caused by alcohol abuse.

Noopept is absorbed easily into the body from the gastrointestinal (GI) tract, and quickly crosses the blood-brain barrier. It only takes about 15 to 20 minutes to work. Once in the brain, the substance binds with glutamate receptor sites and stops the glutamate from breaking down. Glutamate, which is widely believed to form a vital role in memory, learning and cognitive processes in general, is a hugely powerful neurotransmitter.

Noopept also has other affects. For instance, it helps to increase the quantity of oxygen in the brain, which is probably why so many users say it helps them to think more clearly. It also improves the brain’s glucose metabolism, providing a more effective source of brain energy.


Noopept is a potent compound and so it needs to be taken with great care not to overdose. Taken correctly, Noopept seldom produces side effects. But overdose of the nootropic drug can lead to headaches, tiredness, irritability, insomnia, nausea and even some quite unpleasant gastrointestinal problems.

Generally the advice given is to start out with a low dosage and to then increase it over time, if (and only if) it is not enough for the required effect. A good rule of thumb is to start out with just 5 mg two or three times a day. It is common for people to increase the dose to 10 to 30 mg a day, possibly even 40 mg a day. Anything over 20 mg three times a day is likely to over-stimulate the glutamate receptors, which is not a good idea.

Those who have taken Noopept daily over long periods of time say that they do become more tolerant to it. One suggested solution is to take a break over weekends.

Even though there is no evidence that Noopept reacts adversely to other drugs, it is best to consult a doctor when taking other medication, or even supplements, at the same time as Noopept.

Research: Benefits and Effects

Generally, Noopept increases brainpower. Because it is regarded as safe, it is often used to improve the overall cognitive performance of students.

The most common benefits include:

  • Increasing the ability to learn
  • Enhancing memory
  • Improving perception and general reflexes
  • Enabling advanced logical thinking
  • Improving mood by reducing anxiety and other symptoms of depression
  • Generally reduces fatigue

Research has shown that Noopept is particularly effective in improving memory function in humans that had cognitive impairment that was caused by cerebrovascular insufficiency, including that caused by trauma. It has also been shown to have very significant anti-oxidant and neuroprotective effects, particularly in the case of oxidative damage. Research that compared normal and Down’s Syndrome cortical neurons suggests that Noopept could be a valuable “therapeutic” drug for treating chronic neurodegenerative disorders and even mental retardation.

Reviews and Experiences

People who have tried Noopept commonly find that it works on different levels, enhancing perception, improving vision as well as sense of smell and hearing, and increasing their ability to focus. They have also found that memory was strongly improved, particularly spatial memory and vividly remembering experiences. The speed of recall also seems to be improved.

Other improvements users have reported include both verbal and writing capabilities, for instance being able to maintain conversations for longer and with a lot less effort. Generally people seem to experience improved mental energy which some describe as getting rid of “brain fog,” so that everything becomes much simpler and clearer.

Some people have reported that they felt as though they were tripping when they experimented with higher doses of Noopept, but they didn’t experience hallucinations. One described the experience as similar to having the “cognitive improvements” he’d got from LSD, but without any hallucinations at all.

Some men have said that the libido is lowered, but instead of seeing people of the opposite sex as sexual objects, they find they appreciate the beauty of the female body more.

While not all experiences are identical by any means, some have reported an indirectly euphoric effect in terms of feelings towards people and things like music and nature.

Ultimately, most users seem to agree that when they use Noopept as a supplement, their drive, motivation, brainpower and productivity all increase.

Oftentimes, the advice given sounds something similar to, "The secret is to stay smart when using any type of 'study drug.'”

Please note that legality of Adrafinil (whether it's legal as a Research Chemical or for Human Consumption) varies from country to country. Please be aware of the legality of this drug in your country. This article is here as a general resource only. We do not encourage or recommend the consumption of drugs that are against the law in your country. As always, consult your doctor before starting a new diet or fitness program.

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